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Chris Notap carried out his own experiment to mimic the effects on the body in the hope it will encourage people to quit for good

For optogenetic experiments on freely moving mice, an optical fiber (200 m core, NA = 0.39, Thor Labs) coupled to a ferule (1.25 mm) was implanted just above the VTA ipsilateral to the viral injection (coordinates from bregma: AP 3.1 mm, ML 0.5 mm, DV 4.4 mm from the skull), and fixed to the skull with dental cement (SuperBond, Sun Medical)

Preferred Flavors and reasons for E-cigarette use and discontinued use among never, current, and former smokers

A 2021 study involving 289 participants concluded that smokers had a lower testosterone level than non-smokers