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But, these effects can also lead to dependence and increased difficulty in quitting

and a follow-up e-letter rebutting pharmacology meta-analysis editors' suggestion that blinding issues in drug addiction studies are no different than concerns seen in other studies, Polito JR, Why cessation blinding concerns differ from other clinical trials, E-Letter, Canadian Medical Association Journal, November 9, 2008

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Because nicotine pouches like Zyn are relatively new to the market, long-term research is still limited