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6-phosphofructose-2-kinase/fructose-2, 6-bisphosphatase (PFK2) isomer (L-PFK2) was induced by M1 activation, converted into a more active form (u-PFK2), and led to the accumulation of fructose-2, 6-diphosphate, which promoted intracellular aerobic glycolysis (57)
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