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Here, we use single-cell RNA-sequencing (scRNA-seq) to define the transcriptional cell types and states of the tracheal airway epithelium in smokers and non-smokers, infer the lineage relationships among these cells, and determine the influence of cigarette smoke on individual surface and SMG airway epithelial cell types with single-cell resolution

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"Consumers simply do not know what additional chemicals or harmful substances may be present." In 2011, Canada's national police force warned that adulterated cigarettes could contain significantly more cadmium, lead, tar and carbon monoxide than standard cigarettes