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The primary pharmacokinetic interactions with smoking occur with drugs that are CYP1A2 substrates, such as caffeine, clozapine, fluvoxamine, olanzapine, tacrine, and theophylline

Chronic nicotine use also leads to changes in multiple neurotransmitter systems, particularly increasing dopamine release in the reward pathway and altering nicotinic acetylcholine receptors (nAChRs)

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Keep in mind the teenage years are a time of exploration, experimentation and rebellion