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Conclusion and Perspectives Nicotine when combined with a HFD leads to NAFLD through multiple mechanisms, summarized in Figure 2, including generation of severe oxidative stress and increased hepatocellular apoptosis as well inducing adipose tissue lipolysis resulting in excess delivery of FFA and perturbation of hepatic lipid homeostasis through inactivation of AMPK

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SB-793 was initially passed two years ago, but it never ended up taking effect after a number of legal challenges by tobacco companies tied up the legislative proceedings