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Achieving this can be challenging and great care has to be given when choosing exposure dose ranges, which can be based on (i) animal to human exposure conversion factors for in vivo studies [82] and (ii) human data for in vitro studies [83, 84]

That perception is only partially accurate

Or, in other cases, tobacco is used as a complementary flavor note (vanilla caramel tobacco, for example)

Unfortunately, due to focused marketing by companies, individuals that are younger and/or from marginalized ethnic backgrounds disproportionately use menthol-containing products (146149), which has led to notable health disparities within our society