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However, studies have shown that ilioprost (a synthetic analogue of prostacyclin PGI2) has better safety profile than rTPA and is most effective up to 48 hours after rewarming [77, 78]

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China National Tobacco Corporation stands apart as the world's largest cigarette producer by volume, operating as a state monopoly within China, while Philip Morris International, British American Tobacco, Japan Tobacco International, and Imperial Brands compete fiercely across international markets

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