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El motivo es que en estos casos se suele incidir en una de sus caractersticas diferenciadoras: la multiplicidad de intereses que confluyen en ellas y que hace sumamente compleja su aplicacin

Abbreviations A: Area AUC: Area under the curve BAL: Broncho-alveolar lavage COPD: Chronic obstructive pulmonary disease cDC: Conventional dendritic cell CS: Cigarette smoke CSt: Static compliance CXC : CXC Chemokine ECA: E-cigarette aerosol H : Hysteresis IL: Interleukin PAHs: Polycyclic aromatic hydrocarbons PFA: Paraformaldehyde PV: Pression/Volume Th: Thelper cells TNF-: Tumor-necrosis factor- References Gordon T, Karey E, Rebuli ME, Escobar YH, Jaspers I, Chen LC

These definitions are given after centuries of debate, but not everyone agrees