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58 When NDP52 is recruited to damaged mitochondria, it is oxidized and forms disulfide-linked conjugates on the damaged mitochondria, which promotes the association of its SKICH domain with RB1 inducible coiled-coil 1 (FIP200, one of the important components of unc-51 like autophagy activating kinase 1 (ULK1) complex) and consequently exposes the membrane binding site within the CC domain of FIP200

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For the whole sample, we observed an overall, sustained 50% reduction in smoking or smoking abstinence in 37/40 (92.5%) of participants and an overall 75% reduction in median cigarettes per day from 25 to six was observed by the end of the 12 weeks