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Medical and public health organizations, such as the World Health Organization (WHO), consistently advise against the use of any smoked product due to the undeniable harm caused by combustion byproducts

This observation could be due to the limited donor size and the lack of information of non-COPD donors on sex, age and smoking status, which could potentially obscure differences between COPD and control-derived cells with respect to mitochondrial gene expression and methylation

The series' first episode, "Log 1: The Impossible Mission", was filmed in September 1967, a year before the pilot was picked up

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