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Depending on the direction of effect reported in the majority of the studies, we concluded that there were no significant age or sex-based differences in the risk of any cancer following e-cigarette exposure (Figure 4)

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(3) the effect of particle growth on deposition leads to a lower total deposition in the case of combustible tobacco cigarette smoke particles and a higher total deposition in the case of e-cigarette droplets relative to their initial size distributions