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The withdrawal symptoms of nicotine addiction include irritability, anxiety, depression, concentration problems, insomnia, and restlessness , which typically peak within the first week of abstinence and gradually decrease over 3-4 weeks, though some reports indicate they persist beyond a month

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Pandi-Perumal Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA Ke Pang Anesthesiology Department of The Third Xiangya Hospital, Central South University, Changsha, China Ke Pang Division of Health Policy and Management, University of Minnesota, Minneapolis, MN, USA Romil R

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