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First, due to the cross-sectional study design, a causal relationship between HTPs use and the risk of diseases was not guaranteed

Young adult e-cigarette users reasons for liking and not liking e-cigarettes: a qualitative study

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Beyond Pleasure: Aversion Pathways While the mesolimbic dopamine system mediates nicotines rewarding effects, nicotine also activates the medial habenulainterpeduncular nucleus (MHbIPN) circuit, which produces aversive sensations such as nausea at high doses