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Officials decided to take such measures after data appeared in the US on the development of dangerous lung injuries due to the use of e-cigarettes: at least 12 people were hospitalized with severe lung injuries caused by the use of vape

But a 2018 Cochrane Review of three randomized trials in 153 participants found that very high oral doses of 1,000 to 2,000 mcg normalized serum B12 about as well as intramuscular injections

They then use the absence of tobacco for each product as their main highlight, allowing users who are addicted to tobacco to switch to a less harmful alternative

Neal Benowitz, the lead author and a professor of medicine at the University of California, San Francisco, said other recent studies have suggested the drugs are safe for smokers with severe heart disease.