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Inflamed lungs produce more mucous, leading to more frequent asthma symptoms and severe asthma attacks

These in vitro data suggest a slightly reduced potential of next-generation tobacco and nicotine products to induce endothelial dysfunction in comparison to classical cigarette smoking

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Long-Term Effects on Sleep Chronic nicotine useeven from pouchescan have cumulative effects: Reduced sleep efficiency Shortened total sleep time Impaired daytime alertness despite perceived stimulation Potential interaction with circadian rhythms, making early-morning wakefulness more difficult Additionally, nicotine can exacerbate conditions like sleep apnea by increasing airway resistance or promoting arousal from sleep, further compounding sleep disruption