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There were also increases in volunteers heart rates (from an average of 66 beats per minute/bpm to an average of 73bpm) and blood pressure (from an average of 108 millimetres of mercury/mmHg to an average of 117mmHg)

In vitro studies demonstrated tissue- and species-specific differences in dominance of either or neither pathway [66, 84, 88], which could account for the nature of DNA damage and signatures of NNK-mediated carcinogenesis