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Discussion TLRs can recognize various antigens, unleashing a signaling cascade through MyD88, IKK interaction, and ultimately activating the NF-B pathway, a prominent promoter of inflammation and tumorigenesis ( The study presented here shows that complete knockout of either TLR 2, 4, and 9 suppresses the tumor promoting effect of COPD-like lung inflammatory microenvironment, with CC-LR/TLR2KO seeming to manifest the strongest phenotype owing to the highest reduction in tumor burden and accompanied changes in TME