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Conversely, adjusting for gender and exact age at scanning, but looking instead at rate of thinning in current smokers (to avoid confounding this rate by the effect of recovery that is observed in ex-smokers), revealed, within areas of pack-years-associated cortical thinning, that mean cortical thickness was 3.21 m thinner for every pack-year smoked (95% confidence interval, 5.82 to 0.60 m

Unfortunately, after 2 to 3 years, resistance starts to develop in PC against ADT, which is then become castration-resistant prostate cancer (CRPC) (Zhang et al

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