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In addition, stronger regulation of emerging tobacco products is needed to limit exposure to harmful constituents, with an emphasis on protecting youth

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Opioid poisoning, cirrhosis and external mortality We defined opioid deaths using the US Centers for Disease Control and Prevention classification for illicit and prescription-based opioid poisoning, which specifies deaths involving opioid use as a contributory cause using the ICD-10 T-codes or as an external cause of injury using ICD-9 E-codes (Supplementary Table 2)