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Of significance, it was found that male smoking caused an increased risk of pregnancy loss ( p = 0.029), while female smoking caused an adverse effect on ovarian reserve

The results of biomarker analysis showed that linear support vector machine classifiers achieved an area under the receiver operating characteristic curve (AUC) of 0.82 and 0.86 to detect a patient with type II CRC and type II adenoma, respectively, while logistic regression classifiers achieved an AUC of 0.84 and 0.86 to detect a patient with type II CRC and type II adenoma, respectively (Supplementary file: Figures 58 and Tables 12 and 13)

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