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Policymakers should only expand the nicotine marketplace when they have robust independent evidence documenting the safety and effectiveness of these products as smoking cessation aids

The focus on smokeless tobacco, a broad and ambiguous grouping of tobacco products, in existing attempts to quantify health risks has also obscured the distinct risk patterns associated with chewed and non-chewed forms of smokeless tobacco

According to Fennell, A.s 2020 study, Phasic Dopamine Release Magnitude Tracks Individual Differences in Sensitization of Locomotor Response following a History of Nicotine Exposure., repeated nicotine exposure significantly decreases dopamine release in the nucleus accumbens (NAc) core of the brain through changes in 62 receptor modulation

Cummings, K