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Chronic alcohol use changes brain chemistry, creating dependence, cravings, and withdrawal symptoms that can be severe, including tremors, seizures, and delirium tremens in extreme cases.

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The latter represents a substantial improvement compared to the number of deaths in ongoing smokers 69-73 which was 643.01 per 100,000 per year (third row of the table) but among the never smokers aged 59-63 (second row of the table) there were only 91 lung cancer deaths in 291,341 person-years or 31.23/100,000 per year