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"Most smokers start before adulthood, at a time when the capacity for rationalised, long-term decision-making is not yet fully developed

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The combination of abnormal dopamine neurotransmission and nAChR signaling, along with imbalances in glutamate and GABA transmission, which influences the former dysfunctions, may lead to the widespread deficits and symptoms observed in SZ ( Tobacco Use and Antipsychotic Medication Cigarette smoking has been found to increase activity of the liver enzyme, cytochrome P450 1A2 (CYP 1A2), which in turn break down drugs in the body, including antipsychotic medications such as olanzapine and clozapine (112)

Because he was in a high-risk group, his doctor recommended that he have another CT scan six months later