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Notably, a proof-of-principle, randomized, double blind, placebo-controlled study of GS-9450 (selective inhibitor of caspases 1, 8, and 9) suggests that reducing hepatocellular apoptosis may be a valuable therapeutic strategy in patients with NASH (39)

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The fine for the owner of a restaurant, pub, bar and workplace that breaks the smoking law is a maximum of R50 000 and for the individual smoker R500 The tobacco industry can no longer use viral marketing like parties to target young people The sale of tobacco products to and by persons under the age of 18 years is prohibited Cigarette vending machines that sell tobacco products cannot be used to sell other products like crisps, chocolates etc