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A meta-analysis of serum and plasma OPN published in 2014 found pooled specificity and sensitivity of 0.81 (95 percent confidence interval: 0.79-0.84) and 0.57 (95 percent confidence interval: 0.52-0.61), respectively, with significant heterogeneity across the nine studies
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First, accounts of Mississippians in Alabama written by sixteenth-century Spanish explorers suggest chiefdoms were present at that time
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