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[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Bernstein DM
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When someone consumes nicotine, it reaches the brain within seconds, binding to nicotinic acetylcholine receptorsand triggering neurochemical changes that create both immediate pleasure and can lead to longtermphysiological dependence
Using high-strength nicotine salt e-liquids , such as 5%, increases the risk of addiction and may cause side effects like increased heart rate and blood pressure
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