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By overexpression of At TPC1 in these cells, these authors observed a co-suppression of the endogenous channels and used this as proxy to analyse a loss-of-function phenotype, making use of aequorin as calcium reporter

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b , Scatterplot showing read counts and correlation between two independent experimental replicates

It is important to note that classifications do not indicate the size of the risk but are important in supporting health agencies worldwide as they implement actions to limit exposures to known, probable and possible carcinogens