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These studies account for the level of nicotine in the participant's system by allowing frequent smoke breaks so as to avoid inducing a state of withdrawal ( Interestingly, this effect is specific to those with schizophrenia, as no such finding was observed in patients with major depression, bipolar disorder or non-psychiatric controls ( Other studies employed cognitive testing in both satiated and abstinent states and demonstrated that smokers with SZ show improvements in various cognitive domains (1

Dopamine is released in the mesolimbic area, corpus striatum, and frontal cortex.3 Dopamine signals a pleasurable experience and plays a critical role in nicotine addiction

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Basez T, Majmundar A, Cruz TB, Allem JP, Unger JB