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Interestingly, several animal models associated with elevated levels of proinflammatory cytokines such as sepsis, ischemiareperfusion, and pancreatitis show improvement by stimulation of the vagus nerve, which is believed to be mediated via activation of 7 nAChRs on macrophages [22]

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Cigarette commercials were banned from US television just a few months later, on January 2, 1971