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As the number of individuals smoking cigarettes in California has decreased, so has the total amount of cigarette purchases by California consumers

Tobacco smoking has already been one of the worlds largest health problems for many decades

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Sustained NRF2 activation probably contributes to persistent antioxidant defense and cellular resilience during long-term oxidative challenge, consistent with observations that NRF2 signaling remains constitutively active in smoking-associated squamous carcinomas 29,30