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Saliva Collection, Preparation, and UPLC-MS Sixteen saliva samples were collected for the metabolomic analysis using ultraperformance liquid chromatographymass spectrometry (UPLC-MS), comprising of 11 samples from healthy individuals and five samples from OSCC patients ( Supplementary Table S1 )

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One of the current smokers also reported feeling ashamed about their own personal smoking habits, and said this shame could be productive for quitting: Whenever I see warning labels, it kind of makes me feel a little ashamed to smoke so many cigarettes