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The closer the alternative nicotine products mimic what smokers seek from their cigarettes, the more effective they can be expected to be in helping smokers quit although this could also increase their potential to create dependence in novice users

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These findings provide a robust methodological platform for tobacco research as well as mechanistic insights into how prolonged smoke exposure promotes epithelial adaptation, revealing NRF2-dependent resilience as a crucial early marker in smoking-related lung cancer development