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This hippocampal hyperactivity can be normalized by hippocampal chemical inactivation [26, 32], or by pharmacologically facilitating GABA signaling through direct hippocampal infusion of either a nonselective (the benzodiazepine midazolam) [33] or selective positive allosteric modulator (PAM) for 5-subunit-containing GABA A receptors [33, 34]

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