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Juul Labs is fully committed to the Premarket Tobacco Product Application (PMTA) process in the United States, and to that end has built a robust scientific research program to help assess the harm-reduction potential of JUUL products, including their impact on the individual user, their ability to move adult smokers away from combustible cigarettes, and the net-population impact on public health

A notable study by Sepaniak et al ., found that smokers have a significantly higher degree of DNA fragmentation compared to non-smokers