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Whilst a flat-rate tax versus one graded on different nicotine strengths is favored so as not to deter smokers who rely on higher concentrations of nicotine when they start transitioning over to vapes, the additional cost of 2.64 (including VAT) per 10 ml of e-liquid is a kick in the teeth for former adult smokers who have switched to vaping to quit their habits

Nicotine also triggered a shift in the production of the nAChR subunits 3, 5, 7, 2, and 4, as shown by RT-PCR and immunoblotting

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