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Both groups have shown significant declines in smoking over time, but the decline has been greater among young college nongraduates (25 points) than among young college graduates (10 points)

This proposed lineage relationship between tuft-like cells, ionocytes, and PNECs may relate to our observation of an age-dependent balance of rare cell ratios and the recently reported tuft-like variants of small cell lung cancer, generally thought to be a PNEC-derived tumor 58

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