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In total, the research included 120 smokers aged at least 16 years, in Glasgow and Edinburgh, in 20 small groups based on age, gender, and social stratum, how they felt about seeing the warning on every cigarette

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"I have become death, the destroyer of worlds," he said in an interview in 1965

Nicotine could contribute to this progression by aggravating vasoconstriction, although other tobacco smoke toxins are also likely to be contributing to progressive vascular injury. In laymans terms this tells us that nicotines impact as a vasoconstrictor (shrinking blood vessels which increases blood pressure) can contribute, alongside the other chemicals in cigarette smoke, to more severe conditions brought about by prolonged hypertension