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To further confirm this chain of causal inference, we implemented a modified Mendelian randomisation (MR) analysis to investigate potential causal effects by introducing non-pleiotropic polygenic risk scores (PRS) as instrument variables, i.e., the valid-PRS (see Methods for more details) 35,36

Droughts are not uncommon and, despite the fact that historical evidence suggests they have always been a problem in the region, many blame irresponsible loggers in the more northerly countries on the Mekong for exacerbating the situation