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Apart from chemicals, tobacco itself is a highly addictive agent

[16] Alternatively, it could have originated in the Safavid dynasty of Persia, [9] [17] [18] from where it eventually spread to the Indian subcontinent

As more nicotine gets absorbed into the bloodstream, symptoms become severe and can include: Diarrhea Hyperactivity Drooling Constricted pupils Difficulty breathing Increased heart rate and blood pressure Tremors and muscle twitching Weakness/lethargy Convulsions Ataxia (lack of muscle coordination) Seizures How To React if Your Dog Eats a Nicotine Pouch

Yes, long-term smoking accelerates ovarian decline