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Family history Roughly 5 to 10% of people diagnosed with pancreatic cancer have a family history of the disease

show similar up-regulation of PanIN lesion formation, inflammation, fibrosis and stellate cells activation in the same animal model, but with a shorter exposure to cigarette smoke (6 weeks) (38)

NNK is a high-affinity agonist of -adrenergic receptors and nicotinic acetylcholine receptors (nAChR), particularly the 7 isoform, and could influence the development and progression of pancreatic diseases through these receptor-mediated pathways

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