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Taken together, a significant reduction in carcinogenesis endpoints in vitro and tumor formation in vivo would demonstrate that a cMRTP aerosol is less tumorigenic than cigarette smoke

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Dynamics resemble other cases of a population shift from one product to another Taking the full context into account not just the rise in vaping in isolation but the concomitant decline in smoking the dynamics start to look like the population shifting from one product to another, while maintaining an overall steady or slightly declining prevalence of any nicotine use