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There are anatomic differences in the lung that persist for years after smokers quit and gene activity also remains altered. Light Smokers and COPD Smokings effect on lung function explains why smokers are more likely to develop chronic obstructive pulmonary disease (COPD), which is diagnosed when lung function dips below a certain threshold

Histology isnt routinely performed, several pathologic patterns of lung injury have been reported in the setting of vaping such as lipoid pneumonia, diffuse alveolar damage, acute eosinophilic pneumonia, organizing pneumonia, diffuse alveolar haemorrhage, respiratory bronchiolitis interstitial lung disease, hypersensitivity pneumonitis and giant cell interstitial pneumonia, prompting the heterogeneity of the underlying disease processes

Updated May 23, 2025

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