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When companies market these products using imagery that misleads a child into thinking theyre things theyve consumed before, like a juice box or candy, that can create an imminent risk of harm to a child who may confuse the product for something safe and familiar," said FDA Commissioner Scott Gottlieb.[96] Nicotine toxicity is of concern when e-cigarette solutions are swallowed intentionally by adults as a suicidal overdose.[97] Seizures or convulsions are known potential side effects of nicotine toxicity and have been reported in the scientific literature in relation to intentional or accidental swallowing of e-liquid.[72] Six people attempted suicide by injecting e-liquid.[52] One adolescent attempted suicide by swallowing the e-liquid.[17] Three deaths were reported to have resulted from swallowing or injecting e-liquid containing nicotine.[52] An excessive amount of nicotine for an adult that is capable of being fatal is 0.51 mg/kg of body weight.[15] An oral lethal dose for adults is about 3060 mg.[38] However the widely used human LD 50 estimate of around 0.8 mg/kg was questioned in a 2013 review, in light of several documented cases of humans surviving much higher doses

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5 Although this did not occur systematically across jurisdictions, the warnings also appeared on print advertisements and billboards, by virtue of a mixture of voluntary agreements and legislation

A person co-infected with hepatitis C and HIV: May have more difficulty getting an accurate hepatitis C test result (i.e., may be more likely to get a false-negative or indeterminate test reading)