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J Clin Invest 128:24062418 Vogelmeier CF, Criner GJ, Martnez FJ, Anzueto A, Barnes PJ, Bourbeau J, Celli BR, Chen R, Decramer M, Fabbri LM, Frith P, Halpin DM, Lpez Varela MV, Nishimura M, Roche N, Rodrguez-Roisin R, Sin DD, Singh D, Stockley R et al (2017) Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 Rreport: GOLD Eexecutive Ssummary

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Several of these compounds are confirmed human carcinogens, with increasing evidence that they contribute to bladder cancer in smokers in particular