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Pharmacokinetics of inhaled cannabis The bioavailability of cannabinoids differs depending on the route of consumption, with marked differences in bioavailability between oral and inhaled cannabis due to its lipophilic characteristics, poor aqueous solubility, and significant first-pass metabolism [36, 37]

In the U.S., for example, one study estimated that a 2009 ban on non-menthol flavorings reduced teenage cigarette use by 17%

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