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To reduce the effect of bias, we adjusted observations that did not account for more than five confounders, including age and sex, because they were the significant bias covariates identified by the bias covariate selection algorithm 29 (Supplementary Table 7)

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Safer Smoking Practices For those concerned about potential disease transmission while enjoying cannabis socially, several practices can reduce risk: Personal Tips Avoid sharing when you or others have visible cold sores Consider using personal mouthpieces or tips that can be attached to joints Maintain good oral hygiene before social smoking sessions Be open about active infections to protect others While mastering joint rolling techniques is important for the experience, mastering safe sharing practices is equally crucial for health