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Fluoroquinolones, including ciprofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions that have occurred together (5.1), including: o Tendinitis and tendon rupture (5.2) o Peripheral neuropathy (5.3) o Central nervous system effects (5.4) Discontinue ciprofloxacin immediately and avoid the use of fluoroquinolones, including ciprofloxacin tablets, in patients who experience any of these serious adverse reactions (5.1) Fluoroquinolones, including ciprofloxacin, may exacerbate muscle weakness in patients with myasthenia gravis

however, more and more studies have showed that passive smoking is also a hidden threat [62]