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reported the administration of peg-ADA to reduce extracellular adenosine levels in an LPS-induced mouse model of lung injury compromised resolution of pulmonary inflammation ( Purinergic Signaling in Chronic Pulmonary Inflammation ATP, adenosine, CD73, and CD39 have also been implicated in the pathogenesis of chronic lung inflammation (Figure 4)

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Donor substance use generally showed no association with recipients longitudinal FEV1, although non-risk-adjusted survival was higher when donors were not substance users ( P = .03)