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Stabilized PINK1 recruits and activates cytosolic Parkin, which ubiquitinates multiple OMM proteins, forming polyubiquitin chains that serve as signals for autophagy receptors, including sequestosome 1 (SQSTM1/p62), optineurin (OPTN), NBR1, TAX1BP1, and NDP52/CALCOCO2 [83, 92]

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Lienhard John Fitch Steamboat Museum website Texts on Wikisource: 1743 births 1798 deaths 18th-century American inventors American clockmakers Foundrymen Continental Army soldiers People from Warminster, Pennsylvania People from South Windsor, Connecticut People from colonial Connecticut Suicides in Kentucky 18th-century suicides Clockmakers from the Thirteen Colonies 18th-century American artisans 18th-century American male artists